Russ T. Hepple
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Russ T. Hepple, PhD Room: KNB 426 Phone: (403) 220-8549 Fax: (403) 284-3553 e-mail: hepple@ucalgary.ca Curriculum Vitae To display this information you need Acrobat Reader You can get Acrobat Reader by clicking here [back to HPL members] |
POSITIONS
EDUCATION
RESEARCH INTERESTS
AWARDS AND HONOURS
PROFESSIONAL AFFILIATIONS
CURRENT GRANT SUPPORT
PUBLICATIONS
LAB PERSONNEL
CALL FOR APPLICATIONS
POSITIONS
CIHR Institute of Aging New Investigator
Associate Professor, Faculty of Kinesiology
Associate Professor, Faculty of Medicine, Department of Physiology & Biophysics
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1996-1999 |
Post Doctoral Research Fellow, Department of Medicine, University of California, San Diego, USA |
| 1996 | Ph.D., Department of Physiology, University of Toronto, ON, Canada. |
| 1992 | M.Sc., Department of Physiology, University of Toronto, ON, Canada. |
| 1988 | B.Sc., Department of Physiology, University of Saskatchewan, SK, Canada. |
RESEARCH INTERESTS
A decline in skeletal muscle mass and function plays a significant
role in the deteriorating quality of life with aging and many disease
states (e.g., cardiovascular disease, pulmonary disease, and cancer).
Our research is aimed at understanding the physiological basis for the
decline in skeletal muscle mass and function with aging, how this
decline may be exacerbated by the aforementioned disease states, and
what interventions may be useful in restoring and/or slowing the
decline of skeletal muscle mass and function in these conditions. In
this regard, our recent results show that a decline in mitochondrial
function (rather than content) plays an important role in the decline
in mass-specific aerobic function of skeletal muscle with aging.
Interestingly, long-term caloric restriction (which is one of the only
interventions known to slow aging and increase maximal life span in
mammals) completely prevents the decline in skeletal muscle aerobic
function with aging by maintaining mitochondrial function. As such, a
primary focus of our current research is on identifying the mechanisms
by which caloric restriction protects mitochondrial function with aging
and the extent to which physical activity can mimic this protective
effect.
Recent Awards and Honours.
See Curriculum Vitae (PDF format) for a complete list.
| 2003 | Special Recognition CIHR Institute of Aging New Investigator Award |
| 2003-2008 | CIHR Institute of Aging New Investigator |
| 2002-2007 | Heart & Stroke Foundation of Canada New Investigator Award |
PROFESSIONAL AFFILIATIONS
American Physiological Society
Canadian Federation of Biological Societies
Canadian Society for Exercise Physiology
Gerontological Society of America
American Association for the Advancement of Science
| 2005-2010 | CIHR, Operating Grant: Interventions to maintain skeletal muscle aerobic function with aging. Principal Applicant: $490,000 |
| 2005-2010 | Natural Sciences and Engineering Research Council. Title: Regulation of Performance in Contracting Skeletal Muscle. Principal Applicant. $148,000 |
| 2005-2006 | CIHR, Operating Grant: Mechanisms of Sarcopenia; Principal Investigator; $79,712 |
| 2005 | Pfizer, Research Agreement. Title: Effect of life long exercise on gene expression in aging skeletal muscle: Implications for sarcopenia. Principal Applicant. $123,000 |
| 2004-2005 | Brenda Strafford Foundation Chair in Geriatric Research. Pilot Project Grant. Title: Effect of life long exercise on gene expression in aging skeletal muscle: Implications for sarcopenia and resulting frailty. Principal Applicant. $24,500 |
| 2003-2006 | Canadian Institutes of Health Research, Special Science of Aging Knowledge Environment (SAGE-KE) Grant. Title: The Physiology of Aging Skeletal Muscle; (Contributing Editor to SAGE-KE online journal). Principal Applicant. $15,000 |
| 2002-2005 | Canadian Institutes of Health Research, Operating Grant. Title: Influence of Sarcopenia on Aerobic Performance in Aged Skeletal Muscles. Principal Applicant. $257,244 |
To view Russ T. Hepple's publications please see his Curriculum Vitae (PDF format)
LAB PERSONNEL
David Baker, Ph.D. (Supervisor, Postdoctoral Fellow)
Jason Villarin, Ph.D. (Supervisor, Postdoctoral Fellow)
Peyman Shooshtari, M.D. (Supervisor, Clinician Scientist, Faculty of Kinesiology)
Andrew Betik (Supervisor, Ph.D. program, Faculty of Kinesiology)
Melissa Thomas (Supervisor, Ph.D. program, Faculty of Kinesiology)
Marina McConkey (Supervisor, M.Sc. program, Faculty of Kinesiology)
Dan Krause, M.Sc. Research Assistant
CALL FOR APPLICATIONS
We are currently seeking a PhD candidate to work on our NSERC funded
grant on projects related to the interactions between mitochondrial
oxidative capacity and oxygen delivery as determinants and regulators
of aerobic metabolism in contracting skeletal muscles. Individuals with
their own funding, or a strong potential for garnering such support,
will be given priority. Interested individuals should contact Dr.
Hepple by email (hepple@ucalgary.ca).